Yes, apply differin after you have washed your face. You should wait for at least 20 minutes before applying the medication in order to make sure your face is fully dried. You may apply moisturizer after the differin but have to wait at least 30 minutes. And in the morning wash face with a gentle face wash. Maybe Cetaphil Gentle Wash because that is very gentle on your skin.

yayy that helped me a lot.

yes, sleep with it your face works best at night then rinse your face with preferably cetaphil gentle wash and apply moisturizer with spf before heading out since it will make you skin sensitive to sunlight and dryness will appear.