Tinnitus or ringing in the ear has been reported by some persons who have used Advair Diskus 250/50 and 100/50. Based on post-marketing reports, this represents only less than one percent of those who claim they experienced side effects. Severity of the symptoms was not included in their report. The condition was also linked to separate use of prednisone. It should be noted, however, that prolonged use of antihistamine and antibiotics for controlling allergy and sinus infections can also cause a type of tinnitus called sinusitis tinnitus. It is best to consult your doctor regarding your condition to explore treatment options.